Week 18 Games
| Date (Day) | Home Team | Score | Score | Away Team | Location | |||||
| Jan 3, 1981 (Sat) | Philadelphia Eagles | 31 | 16 | Minnesota Vikings | Veterans Stadium | standings | ||||
| Jan 3, 1981 (Sat) | San Diego Chargers | 20 | 14 | Buffalo Bills | San Diego Stadium | standings | ||||
| Jan 4, 1981 (Sun) | Cleveland Browns | 12 | 14 | Oakland Raiders | Cleveland Municipal Stadium | standings | ||||
| Jan 4, 1981 (Sun) | Atlanta Falcons | 27 | 30 | Dallas Cowboys | Atlanta-Fulton County Stadium | standings |