Week 5 Games
| Date (Day) | Home Team | Score | Score | Away Team | Location | |||||
| Oct 25, 1959 (Sun) | Cleveland Browns | 34 | 7 | Washington Redskins | Cleveland Municipal Stadium | standings | ||||
| Oct 25, 1959 (Sun) | Chicago Cardinals | 24 | 28 | Philadelphia Eagles | Soldier Field | standings | ||||
| Oct 25, 1959 (Sun) | Pittsburgh Steelers | 16 | 21 | New York Giants | Forbes Field | standings | ||||
| Oct 25, 1959 (Sun) | Baltimore Colts | 38 | 21 | Green Bay Packers | Memorial Stadium | standings | ||||
| Oct 25, 1959 (Sun) | Los Angeles Rams | 7 | 17 | Detroit Lions | Los Angeles Memorial Coliseum | standings | ||||
| Oct 25, 1959 (Sun) | San Francisco 49ers | 20 | 17 | Chicago Bears | Kezar Stadium | standings |