Week 1 Games
| Date (Day) | Home Team | Score | Score | Away Team | Location | |||||
| Sep 26, 1959 (Sat) | Pittsburgh Steelers | 17 | 7 | Cleveland Browns | Forbes Field | standings | ||||
| Sep 26, 1959 (Sat) | Los Angeles Rams | 21 | 23 | New York Giants | Los Angeles Memorial Coliseum | standings | ||||
| Sep 27, 1959 (Sun) | Green Bay Packers | 9 | 6 | Chicago Bears | New City Stadium | standings | ||||
| Sep 27, 1959 (Sun) | Baltimore Colts | 21 | 9 | Detroit Lions | Memorial Stadium | standings | ||||
| Sep 27, 1959 (Sun) | San Francisco 49ers | 24 | 14 | Philadelphia Eagles | Kezar Stadium | standings | ||||
| Sep 27, 1959 (Sun) | Chicago Cardinals | 49 | 21 | Washington Redskins | Soldier Field | standings |