Regular Season
| Week | Date (Day) | Opponent | Location | Score | Result | Record | Overall | ||||
| 5 | Oct 23, 1921 (Sun) | Minneapolis Marines | Hagemeister Park | 7 - 6 | Win | 1-0-0 | 1-0-0 | standings | |||
| 6 | Oct 30, 1921 (Sun) | Rock Island Independents | Hagemeister Park | 3 - 13 | Loss | 1-1-0 | 1-1-0 | standings | |||
| 7 | Nov 6, 1921 (Sun) | Evansville Crimson Giants | Hagemeister Park | 43 - 6 | Win | 2-1-0 | 2-1-0 | standings | |||
| 8 | Nov 13, 1921 (Sun) | Hammond Pros | Hagemeister Park | 14 - 7 | Win | 3-1-0 | 3-1-0 | standings | |||
| 9 | Nov 20, 1921 (Sun) | @ Chicago Cardinals | Normal Park | 3 - 3 | Tie | 3-1-1 | 3-1-1 | standings | |||
| 10 | Nov 27, 1921 (Sun) | @ Chicago Staleys | Cubs Park | 0 - 20 | Loss | 3-2-1 | 3-2-1 | standings |