Regular Season
| Week | Date (Day) | Opponent | Location | Score | Result | Record | Overall | ||||
| 1 | Sep 13, 2026 (Sun) | @ Houston Texans | NRG Stadium | 36 - 31 | Win | 1-0-0 | 1-0-0 | stats | standings | ||
| 2 | Sep 17, 2026 (Thu) | Detroit Lions | Highmark Stadium | 41 - 31 | Win | 2-0-0 | 2-0-0 | stats | standings | ||
| 3 | Sep 27, 2026 (Sun) | Los Angeles Chargers | Highmark Stadium | 24 - 16 | Win | 3-0-0 | 3-0-0 | stats | standings | ||
| 4 | Oct 4, 2026 (Sun) | New England Patriots | Highmark Stadium | 26 - 29 | Loss | 3-1-0 | 3-1-0 | stats | standings | ||
| 5 | Oct 12, 2026 (Mon) | @ Los Angeles Rams | SoFi Stadium | 37 - 34 | Win | OT | 4-1-0 | 4-1-0 | stats | standings | |
| 6 | Oct 18, 2026 (Sun) | @ Las Vegas Raiders | Allegiant Stadium | 4:25 PM EDT | |||||||
| 8 | Nov 1, 2026 (Sun) | Baltimore Ravens | Highmark Stadium | 1:00 PM EDT | |||||||
| 9 | Nov 9, 2026 (Mon) | @ Minnesota Vikings | U.S. Bank Stadium | 8:15 PM EST | |||||||
| 10 | Nov 15, 2026 (Sun) | @ New York Jets | MetLife Stadium | 1:00 PM EST | |||||||
| 11 | Nov 22, 2026 (Sun) | Miami Dolphins | Highmark Stadium | 1:00 PM EST | |||||||
| 12 | Nov 26, 2026 (Thu) | Kansas City Chiefs | Highmark Stadium | 8:20 PM EST | |||||||
| 13 | Dec 6, 2026 (Sun) | @ New England Patriots | Gillette Stadium | 4:25 PM EST | |||||||
| 14 | Dec 13, 2026 (Sun) | @ Green Bay Packers | Lambeau Field | 8:20 PM EST | |||||||
| 15 | Dec 19, 2026 (Sat) | Chicago Bears | Highmark Stadium | 8:20 PM EST | |||||||
| 16 | Dec 25, 2026 (Fri) | @ Denver Broncos | Empower Field at Mile High | 4:30 PM EST | |||||||
| 17 | Jan 3, 2027 (Sun) | @ Miami Dolphins | Hard Rock Stadium | 1:00 PM EST | |||||||
| 18 | Jan 10, 2027 (Sun) | New York Jets | Highmark Stadium | 1:00 PM EST | |||||||