| Players Picked at #53 | ||||||||||
| Season | Pick # | Team | Name | Position | College | |||||
| 2025 | 53 | Tampa Bay Buccaneers | Benjamin Morrison | CB | Notre Dame | |||||
| 2024 | 53 | Washington Commanders | Ben Sinnott | TE | Kansas State | |||||
| 2023 | 53 | Chicago Bears | Gervon Dexter | DT | Florida | |||||
| 2022 | 53 | Indianapolis Colts | Alec Pierce | WR | Cincinnati | |||||
| 2021 | 53 | Tennessee Titans | Dillon Radunz | T | North Dakota State | |||||
| 2020 | 53 | Philadelphia Eagles | Jalen Hurts | QB | Oklahoma | |||||
| 2019 | 53 | Philadelphia Eagles | Miles Sanders | RB | Penn State | |||||
| 2018 | 53 | Tampa Bay Buccaneers | M.J. Stewart | CB | North Carolina | |||||
| 2017 | 53 | Detroit Lions | Teez Tabor | CB | Florida | |||||
| 2016 | 53 | Washington Redskins | Su'a Cravens | LB | USC | |||||
| 2015 | 53 | Cincinnati Bengals | Jake Fisher | T | Oregon | |||||
| 2014 | 53 | Green Bay Packers | Davante Adams | WR | Fresno State | |||||
| 2013 | 53 | Cincinnati Bengals | Margus Hunt | DE | SMU | |||||
| 2012 | 53 | Cincinnati Bengals | Devon Still | DT | Penn State | |||||
| 2011 | 53 | Chicago Bears | Stephen Paea | DT | Oregon State | |||||
| 2010 | 53 | New England Patriots | Jermaine Cunningham | DE | Florida | |||||
| 2009 | 53 | Philadelphia Eagles | LeSean McCoy | RB | Pittsburgh | |||||
| 2008 | 53 | Pittsburgh Steelers | Limas Sweed | WR | Texas | |||||
| 2007 | 53 | Cleveland Browns | Eric Wright | CB | UNLV | |||||
| 2006 | 53 | Dallas Cowboys | Anthony Fasano | TE | Notre Dame | |||||
| 2005 | 53 | Baltimore Ravens | Dan Cody | DE | Oklahoma | |||||
| 2004 | 53 | Seattle Seahawks | Michael Boulware | S | Florida State | |||||
| 2003 | 53 | New York Jets | Victor Hobson | LB | Michigan | |||||
| 2002 | 53 | Oakland Raiders | Langston Walker | T | California | |||||
| 2001 | 53 | Dallas Cowboys | Quincy Carter | QB | Georgia | |||||
| 2000 | 53 | Miami Dolphins | Todd Wade | T | Mississippi | |||||
| 1999 | 53 | Buffalo Bills | Peerless Price | WR | Tennessee | |||||
| 1998 | 53 | Atlanta Falcons | Bob Hallen | C | Kent State | |||||
| 1997 | 53 | Pittsburgh Steelers | Will Blackwell | WR | San Diego State | |||||
| 1996 | 53 | Buffalo Bills | Gabe Northern | DE | LSU | |||||
| 1995 | 53 | Miami Dolphins | Andrew Greene | G | Indiana | |||||
| 1994 | 53 | San Francisco 49ers | Kevin Mitchell | LB | Syracuse | |||||
| 1993 | 53 | New Orleans Saints | Reggie Freeman | LB | Florida State | |||||
| 1992 | 53 | Detroit Lions | Tracy Scroggins | LB | Tulsa | |||||
| 1991 | 53 | San Francisco 49ers | John Johnson | LB | Clemson | |||||
| 1990 | 53 | San Francisco 49ers | Eric Davis | CB | Jacksonville State | |||||
| 1989 | 53 | Los Angeles Rams | Darryl Henley | CB | UCLA | |||||
| 1988 | 53 | Tampa Bay Buccaneers | Lars Tate | RB | Georgia | |||||
| 1987 | 53 | San Diego Chargers | Louis Brock | CB | USC | |||||
| 1986 | 53 | New York Giants | Greg Lasker | S | Arkansas | |||||
| 1985 | 53 | Seattle Seahawks | Owen Gill | RB | Iowa | |||||
| 1984 | 53 | Miami Dolphins | Jay Brophy | LB | Miami (FL) | |||||
| 1983 | 53 | Cincinnati Bengals | Ray Horton | S | Washington | |||||
| 1982 | 53 | Dallas Cowboys | Jeff Rohrer | LB | Yale | |||||
| 1981 | 53 | Dallas Cowboys | Doug Donley | WR | Ohio State | |||||
| 1980 | 53 | Philadelphia Eagles | Perry Harrington | RB | Jackson State | |||||
| 1979 | 53 | Miami Dolphins | Jeff Toews | T | Washington | |||||
| 1978 | 53 | Los Angeles Rams | Ron Smith | WR | San Diego State | |||||
| 1977 | 53 | Baltimore Colts | Mike Ozdowski | DE | Virginia | |||||
| 1976 | 53 | Los Angeles Rams | Ron McCartney | LB | Tennessee | |||||
| 1975 | 53 | Baltimore Colts | Mike Washington | CB | Alabama | |||||
| 1974 | 53 | Dallas Cowboys | Danny White | QB | Arizona State | |||||
| 1973 | 53 | Dallas Cowboys | Harvey Martin | DE | East Texas State | |||||
| 1972 | 53 | Buffalo Bills | Fred Swendson | DE | Notre Dame | |||||
| 1971 | 53 | Buffalo Bills | Bruce Jarvis | C | Washington | |||||
| 1970 | 53 | Pittsburgh Steelers | Mel Blount | CB | Southern | HOF - 1989 | ||||
| 1969 | 53 | Buffalo Bills | Julian Nunamaker | DE | Tennessee - Martin | |||||
| 1968 | 53 | Atlanta Falcons | John Wright | WR | Illinois | |||||
| 1967 | 53 | New Orleans Saints | Dave Rowe | T | Penn State | |||||
| 1966 | 53 | Washington Redskins | Bill Clay | DB | Mississippi | |||||
| 1965 | 53 | Dallas Cowboys | Bob Svihus | T | USC | |||||
| 1964 | 53 | Minnesota Vikings | Tom Keating | DT | Michigan | |||||
| 1963 | 53 | Baltimore Colts | Harlow Fullwood | G | Virginia | |||||
| 1962 | 53 | Cleveland Browns | Stan Sczurek | G | Purdue | |||||
| 1961 | 53 | Philadelphia Eagles | Dan Ficca | G | USC | |||||
| 1960 | 53 | Cleveland Browns | Bob Jarus | RB | Purdue | |||||
| 1959 | 53 | Cleveland Browns | John Wooten | G | Colorado | |||||
| 1958 | 53 | Chicago Bears | Bob Jewett | E | Michigan State | |||||
| 1957 | 53 | Cleveland Browns | Milt Campbell | B | Indiana | |||||
| 1956 | 53 | Los Angeles Rams | Herb Nakken | B | Utah | |||||
| 1955 | 53 | Green Bay Packers | Hank Bullough | G | Michigan State | |||||
| 1954 | 53 | Baltimore Colts | Don Ellis | B | Texas A&M | |||||
| 1953 | 53 | Pittsburgh Steelers | Bob Gaona | T | Wake Forest | |||||
| 1952 | 53 | Dallas Texans | Mel Sinquefield | C | Mississippi | |||||
| 1951 | 53 | San Francisco 49ers | Dick Steere | T | Drake | |||||
| 1950 | 53 | Philadelphia Eagles | Bob McChesney | E | Hardin-Simmons | |||||
| 1949 | 53 | New York Bulldogs | Albin Collins | B | LSU | |||||
| 1948 | 53 | Detroit Lions | Moroni Schwab | T | Utah State | |||||
| 1947 | 53 | Los Angeles Rams | Bill Smyth | T | Cincinnati | |||||
| 1946 | 53 | Pittsburgh Steelers | Tom Reinhardt | T | Minnesota | |||||
| 1945 | 53 | New York Giants | Barney Poole | E | Mississippi | |||||
| 1944 | 53 | Cleveland Rams | Al Akins | B | Washington State | |||||
| 1943 | 53 | Chicago Cardinals | Stan Mauldin | T | Texas | |||||
| 1942 | 53 | Philadelphia Eagles | Billy Sewell | B | Washington State | |||||
| 1941 | 53 | Pittsburgh Steelers | Jim Roberts | C | Marshall | |||||
| 1940 | 53 | Pittsburgh Steelers | Pete Cignetti | B | Boston College | |||||
| 1939 | 53 | Cleveland Rams | Jerry Dowd | C | St. Mary's (CA) | |||||
| 1938 | 53 | Brooklyn Dodgers | Leroy Monsky | G | Alabama | |||||
| 1937 | 53 | Brooklyn Dodgers | John Golemgeske | T | Wisconsin | |||||
| 1936 | 53 | Detroit Lions | Abe Mickal | B | LSU | |||||
