| Players Picked at #12 | ||||||||||
| Season | Pick # | Team | Name | Position | College | |||||
| 2025 | 12 | Dallas Cowboys | Tyler Booker | G | Alabama | |||||
| 2024 | 12 | Denver Broncos | Bo Nix | QB | Oregon | |||||
| 2023 | 12 | Detroit Lions | Jahmyr Gibbs | RB | Alabama | |||||
| 2022 | 12 | Detroit Lions | Jameson Williams | WR | Alabama | |||||
| 2021 | 12 | Dallas Cowboys | Micah Parsons | LB | Penn State | |||||
| 2020 | 12 | Las Vegas Raiders | Henry Ruggs III | WR | Alabama | |||||
| 2019 | 12 | Green Bay Packers | Rashan Gary | LB | Michigan | |||||
| 2018 | 12 | Tampa Bay Buccaneers | Vita Vea | DT | Washington | |||||
| 2017 | 12 | Houston Texans | Deshaun Watson | QB | Clemson | |||||
| 2016 | 12 | New Orleans Saints | Sheldon Rankins | DT | Louisville | |||||
| 2015 | 12 | Cleveland Browns | Danny Shelton | DT | Washington | |||||
| 2014 | 12 | New York Giants | Odell Beckham, Jr. | WR | LSU | |||||
| 2013 | 12 | Oakland Raiders | D.J. Hayden | CB | Houston | |||||
| 2012 | 12 | Philadelphia Eagles | Fletcher Cox | DT | Mississippi State | |||||
| 2011 | 12 | Minnesota Vikings | Christian Ponder | QB | Florida State | |||||
| 2010 | 12 | San Diego Chargers | Ryan Mathews | RB | Fresno State | |||||
| 2009 | 12 | Denver Broncos | Knowshon Moreno | RB | Georgia | |||||
| 2008 | 12 | Denver Broncos | Ryan Clady | T | Boise State | |||||
| 2007 | 12 | Buffalo Bills | Marshawn Lynch | RB | California | |||||
| 2006 | 12 | Baltimore Ravens | Haloti Ngata | DT | Oregon | |||||
| 2005 | 12 | San Diego Chargers | Shawne Merriman | LB | Maryland | |||||
| 2004 | 12 | New York Jets | Jonathan Vilma | LB | Miami (FL) | |||||
| 2003 | 12 | St Louis Rams | Jimmy Kennedy | DT | Penn State | |||||
| 2002 | 12 | Arizona Cardinals | Wendell Bryant | DT | Wisconsin | |||||
| 2001 | 12 | St Louis Rams | Damione Lewis | DT | Miami | |||||
| 2000 | 12 | New York Jets | Shaun Ellis | DE | Tennessee | |||||
| 1999 | 12 | Chicago Bears | Cade McNown | QB | UCLA | |||||
| 1998 | 12 | Atlanta Falcons | Keith Brooking | LB | Georgia Tech | |||||
| 1997 | 12 | Tampa Bay Buccaneers | Warrick Dunn | RB | Florida State | |||||
| 1996 | 12 | Tampa Bay Buccaneers | Regan Upshaw | DE | California | |||||
| 1995 | 12 | Tampa Bay Buccaneers | Warren Sapp | DT | Miami (FL) | HOF - 2013 | ||||
| 1994 | 12 | New York Jets | Aaron Glenn | CB | Texas A&M | |||||
| 1993 | 12 | Los Angeles Rams | Patrick Bates | S | Texas A&M | |||||
| 1992 | 12 | Miami Dolphins | Marco Coleman | LB | Georgia Tech | |||||
| 1991 | 12 | Dallas Cowboys | Alvin Harper | WR | Tennessee | |||||
| 1990 | 12 | Cincinnati Bengals | James Francis | LB | Baylor | |||||
| 1989 | 12 | Chicago Bears | Trace Armstrong | DE | Florida | |||||
| 1988 | 12 | Phoenix Cardinals | Ken Harvey | OLB | California | |||||
| 1987 | 12 | Dallas Cowboys | Danny Noonan | DT | Nebraska | |||||
| 1986 | 12 | Detroit Lions | Chuck Long | QB | Iowa | |||||
| 1985 | 12 | San Diego Chargers | Jim Lachey | T | Ohio State | |||||
| 1984 | 12 | Green Bay Packers | Alphonso Carreker | DE | Florida State | |||||
| 1983 | 12 | Buffalo Bills | Tony Hunter | TE | Notre Dame | |||||
| 1982 | 12 | Pittsburgh Steelers | Walter Abercrombie | RB | Baylor | |||||
| 1981 | 12 | Baltimore Colts | Randy McMillan | RB | Pittsburgh | |||||
| 1980 | 12 | New Orleans Saints | Stan Brock | T | Colorado | |||||
| 1979 | 12 | Cincinnati Bengals | Charles Alexander | RB | LSU | |||||
| 1978 | 12 | Cleveland Browns | Clay Matthews | LB | USC | |||||
| 1977 | 12 | Buffalo Bills | Phil Dokes | DT | Oklahoma State | |||||
| 1976 | 12 | New England Patriots | Pete Brock | C | Colorado | |||||
| 1975 | 12 | New Orleans Saints | Kurt Schumacher | T | Ohio State | |||||
| 1974 | 12 | Green Bay Packers | Barty Smith | RB | Richmond | |||||
| 1973 | 12 | Minnesota Vikings | Chuck Foreman | RB | Miami (FL) | |||||
| 1972 | 12 | Chicago Bears | Craig Clemons | S | Iowa | |||||
| 1971 | 12 | Denver Broncos | Marv Montgomery | T | USC | |||||
| 1970 | 12 | Atlanta Falcons | John Small | LB | The Citadel | |||||
| 1969 | 12 | Green Bay Packers | Rich Moore | DE | Villanova | |||||
| 1968 | 12 | Washington Redskins | Jim Smith | DB | Oregon | |||||
| 1967 | 12 | New York Jets | Paul Seiler | G | Notre Dame | |||||
| 1966 | 12 | Chicago Bears | George Rice | T | LSU | |||||
| 1965 | 12 | St. Louis Cardinals | Joe Namath | QB | Alabama | HOF - 1985 | ||||
| 1964 | 12 | New York Giants | Joe Don Looney | B | Oklahoma | |||||
| 1963 | 12 | Detroit Lions | Daryl Sanders | T | Ohio State | |||||
| 1962 | 12 | St. Louis Cardinals | Irv Goode | C | Kentucky | |||||
| 1961 | 12 | Green Bay Packers | Herb Adderley | DB | Michigan State | HOF - 1980 | ||||
| 1960 | 12 | New York Giants | Lou Cordileone | DT | Clemson | |||||
| 1959 | 12 | Baltimore Colts | Jackie Burkett | C | Auburn | |||||
| 1958 | 12 | New York Giants | Phil King | FB | Vanderbilt | |||||
| 1957 | 12 | Detroit Lions | Bill Glass | G | Baylor | |||||
| 1956 | 12 | Washington Redskins | Ed Vereb | HB | Maryland | |||||
| 1955 | 12 | Detroit Lions | Dave Middleton | HB | Auburn | |||||
| 1954 | 12 | Cleveland Browns | John Bauer | G | Illinois | |||||
| 1953 | 12 | Los Angeles Rams | Ed Barker | E | Washington State | |||||
| 1952 | 12 | Cleveland Browns | Harry Agganis | QB | Boston Univ. | |||||
| 1951 | 12 | Chicago Bears | Gene Schroeder | E | Virginia | |||||
| 1950 | 12 | Los Angeles Rams | Stan West | G | Oklahoma | |||||
| 1949 | 12 | Detroit Lions | John Panelli | B | Notre Dame | |||||
| 1948 | 12 | New York Giants | Joe Scott | B | San Francisco | |||||
| 1947 | 12 | Detroit Lions | Russ Thomas | T | Ohio State | |||||
| 1946 | 12 | Boston Yanks | Nick Scollard | E | St. Joseph's (IN) | |||||
| 1945 | 12 | Pittsburgh Steelers | Jack Dugger | E | Ohio State | |||||
| 1944 | 12 | Chicago Cardinals | Paul Mitchell | T | Minnesota | |||||
| 1943 | 12 | Phil-Pitt Steagles | Lamar Davis | B | Georgia | |||||
| 1942 | 12 | Cleveland Rams | Jack Jacobs | B | Oklahoma | |||||
| 1941 | 12 | Pittsburgh Steelers | Chet Gladchuk | C | Boston College | |||||
| 1940 | 12 | Pittsburgh Steelers | Ralph Wenzel | E | Tulane | |||||
| 1939 | 12 | Chicago Cardinals | Marshall Goldberg | TB | Pittsburgh | |||||
| 1938 | 12 | Philadelphia Eagles | Dick Riffle | B | Albright | |||||
| 1937 | 12 | Chicago Cardinals | Gaynell Tinsley | E | LSU | |||||
| 1936 | 12 | Pittsburgh Pirates | Len Barnum | B | West Virginia Wesleyan | |||||
